American Standard Stratocaster A best guitar pickup is essentially just like a vibrant mike coil. For many years, energetic microphones have now been wired with the style coil attached with the primary of the microphone's transformer, and not introduced to ground (‘floating'). The microphone's situation is typically connected to the wire shield, that will be connected to the microphone amplifier's floor (see Rane's site for more discussion).
By and large, vibrant microphones are extremely quiet devices consequently of the mixture of transformer isolation and healthy, suspended indication lines throughout, as well as guarded, humbucking coils.
Therefore why not instruments? Instruments are notoriously affected by noise. Humbucking pickups are just an incomplete (though important!) solution. The most obvious alternative would be to float the guitar collection to a balanced output, being a microphone. A similar strategy was printed this 2001 patent application such as American Standard Stratocaster?