Blackstar 1x12 Cab A best guitar collection is essentially much like a powerful mike coil. For decades, powerful microphones have been wired with the voice coil mounted on the principal of the microphone's transformer, and perhaps not called to floor (‘floating'). The microphone's case is typically attached to the wire shield, which will be attached to the mike amplifier's ground (see Rane's site for more discussion).
By and large, energetic microphones are very calm products consequently of the combination of transformer isolation and balanced, floating transmission lines for the duration of, along with shielded, humbucking coils.
Therefore why don't you instruments? Guitars are notoriously overwhelmed by noise. Humbucking pickups are just a partial (though crucial!) solution. The most obvious option would be to move your guitar collection to a balanced production, just like a microphone. A similar thought was published this 2001 patent application such as Blackstar 1x12 Cab?